QZyme Workbench is a fully automated proprietary in silico protein engineering platform, evolved by integrating open-source computational chemistry and biology/bioinformatics tools in combination with customised algorithms and scripts. QZyme Workbench is capable of tackling several important aspects of protein modelling and engineering including, but not limited to, structural refinement, ligand docking, conformational sampling, estimating substrate binding affinity, modelling catalytic reaction, identifying mutable hotspots, further hotspot optimization.